![]() ![]() It’s starting to gradually disappear from our lives because of the wireless era. Then we have what was once the most common audio port, the 3.5mm jack. With lack of storage becoming the massive problem it is today, the HyperDrive dock makes things incredibly easier by hosting not one but two microSD slots that are compatible with not just phones but consoles too. ![]() One is an SD UHS-II port with a 300MB/s speed and the other is a MicroSD UHS-II slot providing the same incredible speed. By sporting two slots of varying SD card sizes, the HyperDrive dock offers immense convenience and practicality. The HyperDrive dock just does so much. It has a single USB-C input port and 18 output ports. I could probably spend hours talking about the the practicality of this dock. ![]() It will ensure less chaos and greater efficiency. Hosting ports for memory card insertion, HDMI and 3.5mm audio cable, the dock is the perfect addition to a hardcore gamer’s gaming setup. Today, we’re looking at one of Hypershop’s latest releases, their HyperDrive 18-in-1 USB-C dock. Fortunately, we were able to get our hands on such a dock. Just the thought of a single adapter being able to host 18 different ports for 18 different uses sounds pretty insane. Still just the concept of an 18-in-1 dock is exciting. We’ve grown past the stage of messy desks and uncountable wire cables tangled together. The following reaction types come pre-installed with CovDock and are shown here for reference.USB-C docks are fairly common today. For more information on designing custom covalent docking reactions, please see Knowledge Base Article 1848. To import any of the following files into Maestro, simply open the Covalent Docking Panel, click on the Reaction Type tab, select Custom from the drop-down menu, and then use the Browse option to load the reaction of interest. Schrödinger has made available several custom reactions that can be used in CovDock studies. Schrödinger’s intuitive graphical user interface, Maestro, provides easy-to-use panels for straightforward set-up of experiments, easy visualization, and efficient analysis of CovDock results. Then the covalent bond is formed for the top scoring complex structures, the covalently attached ligand is sampled, and the complexes are scored using all-atom molecular mechanics with the OPLS force field and VSGB2.0 implicit solvent model. First, CovDock docks the pre-reactive ligand to determine viable poses that bring the reactive group into close proximity with the reactive receptor residue. The resultant accuracy outperforms other docking programs in achieving lower RMS deviations from native co-crystallized structures.ĬovDock performs a series of automated steps based on a simple setup from the Maestro graphical interface or from the command line. Glide quickly samples a large pool of initial poses for the pre-reactive species and Prime simultaneously optimizes the ligand pose and attachment residue to produce a sound physical chemistry. An apparent affinity score, based on the Glide score of pre-reactive and post-reactive poses, is also calculated to estimate binding energies for use in virtual screening.ĬovDock is built upon a foundation of the time-tested Glide docking algorithm and Prime structure refinement methodology for accurate prediction of non-covalently docked poses. Covalent complexes are minimized using the Prime VSGB2.0 energy model to score the top covalent complexes. The receptor reactive residue is then added and sampled to form a covalent bond with the ligand in different poses. unfavorable steric clashes and poor electrostatic contacts are prevented as the reaction proceeds.ĬovDock begins with Glide docking to a receptor with the reactive residue trimmed to alanine. The pre-reactive ligand form occupies the binding pocket with enough residency time to facilitate the reaction of the ligand warhead with the reactive protein residue andĢ. CovDock selects the top covalent complexes using the extensively validated Prime energy model, and calculates an apparent affinity score that captures these essential elements of a successful covalent docking process:ġ. With the recent resurgence in covalent drug research, computational insight into covalent docking is becoming key to understanding how covalent inhibitors can be used to address selectivity and potency challenges.Ĭovalent inhibitors derive their activity not only from the formation of a covalent bond between the target and the ligand but also from stabilizing non-covalent forces in the binding pocket. ![]()
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